Lipid distress syndrome in patients with unstable angina pectoris and different gallbladder conditions

Abstract

Introduction. Cholelithiasis and ischemic heart disease (IHD) are possibly connected by systemic lipid distress syndrome. The aim of our paper was to compare lipid metabolism parameters in patients with IHD on the background of different gallbladder (GB) condition. Methods. We analyzed data of 116 patients with IHD, unstable angina pectoris, which were divided into groups according to GB condition (intact GB; sludge; bent GB body; signs of cholecystitis; cholelithiasis; cholecystectomy). Lipid distress syndrome was diagnosed according to lipidogram parameters. Results. Lipid distress syndrome of different potency was present in all groups. Patients with sludge had the highest levels of total cholesterol (TC), β-lipoproteids (BLP), triglycerides (TG), very low density lipoproteins cholesterol (VLDL-C), atherogenic index of plasma (AIP), Castelli indexes I and II together with the lowest concentration of high density lipoproteins cholesterol (HDL-C). Patients after cholecystectomy were characterized by the lowest levels of TC, TG, VLDL-C and AIP. M/HDL-C ratio was the highest in case of bent GB body (1.75 times higher than in the intact GB group), which was accompanied by the higher levels of TG, BLP, VLDL-C and lower concentration of HDL-C. Conclusions. Values of proatherogenic parameters in the sludge group were higher than in the intact GB group, whereas in the cholecystectomy group they were lower than in the intact GB group. Both Castellі indexes were the highest in patients with sludge and bent GB body; their increase was accompanied by the trend to hyperglycemia.

Key words: cholelithiasis, gall bladder, ischemic heart disease, lipid distress syndrome.